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KMID : 0363420200340030001
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Journal of Korean Oriental Pediatrics
2020 Volume.34 No. 3 p.1 ~ p.17
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Review of Clinical Research for Herbal Medicine Treatment on Refractory Nephrotic Syndrome in Children
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Jang Eun-Ha
Min Sang-Yeon
Kim Jang-Hyun
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Abstract
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Objectives: The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in refractory nephrotic syndrome (RNS).
Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on RNS from the Pubmed, CNKI, OASIS, NDSL, J-stage, and CiNii. The demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study.
Results: 11 RCT studies were selected and analyzed. The children in the control group were given western medicine therapy, and the treatment group was given herbal medicine along with the same western medicine of the control group. The most commonly used herbal medicines were the prescriptions to treat ‘Kidney Deficiency with Blood Stasis (腎虛兼瘀血)’ which composed of ‘Promoting blood circulation (化瘀)’, ‘Diuresis-inducing (利水)’, or ‘Heating Yang (溫陽)’ medicine based on ‘Replenishing Kidney or Spleen (補腎, 補脾)’ medicine. In the treatment group, proteinuria and serum lipid was significantly decreased, serum albumin was significantly increased, and total effective rate was significantly higher than the control group. Hypercoagulation and relapse rate was also significantly reduced. Adverse events were significantly lower in the treatment group.
Conclusions: Herbal medicine treatment on pediatric RNS can be suggested as a new treatment for children who have less response to the conventional therapy. It can also supplement the limitations of the western medicine by reducing adverse events from the steroids and immuno-suppressive agents, and lower the relapse rate as well.
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KEYWORD
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Refractory nephrotic syndrome, Herbal medicine, Children, Complementary and alternative medicine, TCM, Kampo medicine
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